TABLE 2.

Values of pharmacokinetic parameters generated with one-compartment model for critically ill pediatric patients treated with daptomycin (10 mg/kg QD)

Patient no.	Day 1				Day 5
	Clearance (ml/h/kg)	Volume of distribution (liter/kg)	AUC0–∞ (μg · h/ml)	Cmax (μg/ml)	Clearance (ml/h/kg)c	Volume of distribution (liter/kg)	AUC0–24 (μg · h/ml) (ratio)c	Cmax (μg/ml)
1	15.1	0.16	663.9	59.8	9.9 (0.65)	0.28	1,009.9 (1.52)	60.4
2	80.7a	0.26	123.8b	35.4	56.4 (0.69)	0.55	177.3 (1.43)	19.2
3	28.1a	0.28	355.8b	33.9	27.7 (0.98)	0.34	360.1 (1.01)	32.9
4	42.3	0.23	236.5	40.7	15.4 (0.36)	0.26	651.4 (2.75)	49.8

^aRatios of corresponding clearance values to that of patient 1: 5.34 for patient 2 and 1.86 for patient 3.

^bRatios of corresponding AUC_0–∞ values to that of patient 1: 0.19 for patient 2 and 0.53 for patient 3.

^cIn parentheses, ratio of each day 5 value to the corresponding day 1 value.