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MIC and selective inhibition of ATP synthesis (IC50) by TO and TO analogs for different TO-resistant mutantsa
| Compound | SaR1-1 |
SaR4-1 |
SaR5-1 |
SaR6-1 |
||||
|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | MIC (μg/ml) | IC50 (μg/ml) | |
| TO | >64 | >512 | >64 | >512 | >64 | >512 | >64 | >512 |
| FC02-190 | >64 | >512 | >64 | >512 | >64 | >512 | >64 | >512 |
| FcM | 2 | 238 ± 22.1 | 2 | >512 | 2 | 110 ± 9.8 | 2 | >512 |
| Fcm | 8 | >512 | 8 | >512 | 8 | >512 | 8 | >512 |
The “>” sign denotes the highest concentration tested.
