TABLE 1.
PBP occupancy patterns of β-lactam antibiotics and BLIs in K. pneumoniae
| Strain and PBP | IC50 of the indicated drug (mg/liter)a |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BIA | DOR | IPM | MEM | ATM | PIP | CAZ | FEP | MEC | AMOX | AVI | SUL | TAZ | |
| ATCC 43816 | |||||||||||||
| 1a/b | 0.5 | 0.5 | 0.25 | 2 | >256 | 16 | 4 | 1 | >256 | 32 | >256 | >256 | >256 |
| 2 | <0.0075 | <0.0075 | <0.0075 | <0.0075 | 16 | 2 | 256 | 0.12 | <0.0075 | 0.5 | 2 | 16 | 16 |
| 3 | 64 | 1 | 8 | 0.12 | 0.06 | 0.06 | 0.25 | 0.06 | 128 | 8 | >256 | 128 | 128 |
| 4 | 0.015 | <0.0075 | <0.0075 | 0.015 | 32 | 64 | >256 | 2 | >256 | 0.25 | 128 | >256 | >256 |
| 5/6 | 16 | 8 | 1 | 8 | 128 | 64 | >256 | >128 | >256 | 64 | >256 | >256 | >256 |
| MIC | 0.06 | 0.06 | 0.25 | 0.06 | 0.06 | 8 | 0.25 | 0.06 | 0.125 | 32 | 16 | 64 | 256 |
| ATCC 13883 | |||||||||||||
| 1a/b | 0.5 | 1 | 0.25 | 0.5 | 64 | 8 | 4 | 0.5 | >256 | 8 | >256 | >256 | >256 |
| 2 | <0.0075 | <0.0075 | <0.0075 | <0.0075 | 16 | 1 | 128 | 0.12 | <0.0075 | 0.5 | 2 | 16 | 16 |
| 3 | 4 | 0.5 | 0.5 | 0.06 | 0.12 | 0.015 | 0.06 | 0.015 | >256 | 2 | >256 | 128 | 128 |
| 4 | <0.0075 | <0.0075 | <0.0075 | <0.0075 | 8 | 4 | >256 | 1 | 128 | 0.03 | 32 | 32 | 32 |
| 5/6 | 4 | 4 | 0.25 | 2 | >256 | 32 | >256 | >256 | >256 | 32 | >256 | >256 | >256 |
| MIC | 1 | 0.125 | 1 | 0.06 | 0.25 | >32 | 0.5 | 0.125 | >32 | >32 | >256 | 64 | 256 |
a
Concentration of β-lactam that inhibits 50% of Bocillin FL compared to that of a control containing no drug. BIA, biapenem; DOR, doripenem; IPM, imipenem; MEM, meropenem; AMOX, amoxicillin; ATM, aztreonam; MEC, mecillinam (amdinocillin); PIP, piperacillin; SUL, sulbactam; TAZ, tazobactam; AVI, avibactam; CAZ, ceftazidime; FEP, cefepime.