TABLE 1.
Distribution of MICs and geometric mean MICs of micafungin and anidulafungin obtained using EUCAST, ETSD, and ETDIR methods
| Drug | Species (no. of isolates) | Method | MIC (mg/liter)a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GMb | 0.015 | 0.032 | 0.064 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | |||
| Micafungin | C. albicans (21) | EUCAST | 0.018 | 20 | 1 | ||||||||
| ETDIR | 0.021 | 20 | 1 | ||||||||||
| ETSD | 0.021 | 20 | 1 | ||||||||||
| C. parapsilosis (20) | EUCAST | 0.841 | 1 | 7 | 8 | 4 | |||||||
| ETDIR | 1.149 | 2 | 12 | 6 | |||||||||
| ETSD | 1 | 4 | 12 | 4 | |||||||||
| C. tropicalis (23) | EUCAST | 0.033 | 9 | 11 | 2 | 1 | |||||||
| ETDIR | 0.039 | 6 | 14 | 1 | 1 | 1 | |||||||
| ETSD | 0.042 | 3 | 17 | 1 | 1 | 1 | |||||||
| C. glabrata (51) | EUCAST | 0.192 | 20 | 6 | 1 | 1 | 5 | 8 | 10 | ||||
| ETDIR | 0.224 | 19 | 1 | 1 | 4 | 2 | 1 | 6 | 8 | 5 | 4 | ||
| ETSD | 0.178 | 20 | 1 | 5 | 1 | 5 | 5 | 10 | 3 | 1 | |||
| Anidulafungin | C. albicans (21) | EUCAST | 0.016 | 18 | 2 | 1 | |||||||
| ETDIR | 0.021 | 20 | 1 | ||||||||||
| ETSD | 0.021 | 20 | 1 | ||||||||||
| C. parapsilosis (20) | EUCAST | 1.866 | 1 | 4 | 11 | 4 | |||||||
| ETDIR | 2.928 | 1 | 7 | 12 | |||||||||
| ETSD | 3.031 | 1 | 6 | 13 | |||||||||
| C. tropicalis (23) | EUCAST | 0.023 | 18 | 4 | 1 | ||||||||
| ETDIR | 0.038 | 7 | 12 | 1 | 1 | 1 | 1 | ||||||
| ETSD | 0.029 | 15 | 5 | 1 | 1 | 1 | |||||||
| C. glabrata (51) | EUCAST | 0.258 | 8 | 12 | 4 | 4 | 6 | 13 | 4 | ||||
| ETDIR | 0.311 | 16 | 4 | 1 | 5 | 2 | 10 | 12 | 1 | ||||
| ETSD | 0.239 | 20 | 3 | 5 | 5 | 12 | 4 | 2 | |||||
a
The MICs obtained by the ETSD and ETDIR were increased to the concentration of the next 2-fold dilution matching the micafungin dilution scale used for the EUCAST procedure. Numbers in bold indicate resistant isolates.
b
GM, geometric mean.