TABLE 1.
Comparison between KPC-Kp and MDR-AB infections in septic patients hospitalized in the same ICUa
| Variableb | KPC-Kp (n = 128) | MDR-AB (n = 92) | Pc |
|---|---|---|---|
| Age (mean ± SD) (yr) | 60.1 ± 15.9 | 60.6 ± 17.2 | 0.8 |
| Male sex | 89 (69.5) | 64 (69.6) | 1.0 |
| Cause of ICU admission | |||
| Respiratory failure | 34 (26.5) | 17 (18.5) | 0.22 |
| Trauma | 25 (19.5) | 23 (25) | 0.43 |
| Septic shock not caused by KPC-Kp or MDR-AB | 28 (21.8) | 30 (32.6) | 0.1 |
| Stroke | 9 (7) | 0 | 0.02 |
| Cardiac/hemorrhagic shock/postsurgery | 32 (25) | 22 (23.9) | 1.0 |
| Comorbidities | |||
| Chronic liver disease | 4 (3.1) | 4 (4.3) | 0.7 |
| Neoplasm | 15 (11.7) | 7 (7.6) | 0.3 |
| Diabetes | 23 (18) | 18 (19.6) | 0.8 |
| Heart failure | 16 (12.5) | 13 (14.1) | 0.8 |
| Coronary artery disease | 46 (35.9) | 42 (45.7) | 0.1 |
| Chronic renal disease | 11 (8.6) | 12 (13) | 0.3 |
| COPD | 22 (17.2) | 23 (25) | 0.1 |
| Previous hospitalization (90 days) | 56 (43.8) | 18 (19.6) | <0.001 |
| Previous ICU admission (90 days) | 13 (10.2) | 12 (13) | 0.5 |
| Previous surgery (30 days) | 50 (39.1) | 38 (41.3) | 0.7 |
| Previous antibiotic therapy (30 days) | 51 (39.8) | 45 (48.9) | 0.2 |
| Colonization at time of ICU admission | 62 (48.4) | 4 (4.3) | <0.001 |
| Source of infection | |||
| Primary bacteremia | 63 (49.2) | 17 (18.5) | <0.001 |
| CVC-related bacteremia | 25 (19.5) | 4 (4.3) | 0.001 |
| Pneumonia | 55 (43) | 64 (69.6) | <0.001 |
| Catheter-related urinary tract | 27 (21.1) | 0 | <0.001 |
| SSTI | 18 (14.1) | 2 (2.1) | <0.001 |
| Intra-abdominal | 14 (10.9) | 5 (5.4) | 0.2 |
| Isolation of a colistin-resistant strain | 57 (44.5) | 1 (1.1) | <0.001 |
| Other infections during ICU stay | 69 (53.9) | 21 (22.8) | <0.001 |
| Steroid therapy during ICU stay | 15 (11.7) | 58 (63) | <0.001 |
| Length of hospitalization (mean ± SD) (days) | 36.4 ± 23.8 | 30.2 ± 17.2 | 0.03 |
| Length of ICU stay (mean ± SD) (days) | 29.8 ± 23.3 | 22.9 ± 15.7 | 0.01 |
| Length of antibiotic therapy (mean ± SD) (days) | 11.7 ± 8.3 | 9.8 ± 9.7 | 0.1 |
| SAPS II at time of infection onset (mean ± SD) | 37.1 ± 5.6 | 39.2 ± 6.3 | 0.5 |
| SAPS II at time of septic shock onset (mean ± SD) | 43.7 ± 10.7 | 46.4 ± 14.2 | 0.1 |
| 30-day mortality | 57 (44.5) | 78 (84.8) | <0.001 |
a
Data are presented as the number (%), unless otherwise stated.
b
KPC-Kp, Klebsiella pneumoniae carbapenemase-producing K. pneumoniae; MDR-AB, multidrug-resistant Acinetobacter baumannii; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; CVC, central venous catheter; SSTI, skin and soft tissue infection; SAPS, simplified acute physiology score.
c
P values in bold are statistically significant.