TABLE 1.

Assessment of the hypothesis that fT>C_T is the exposure variable more closely linked than fAUC to the pharmacodynamic effect of avibactam in combination with ceftazidime against ceftazidime-resistant P. aeruginosa in the neutropenic mouse lung infection model, using bacterial stasis as the pharmacodynamic endpoint^a

Strainb	MIC (mg/liter)		AVIc
			Static total daily dose (mg · kg−1 · day−1)		%fT>CT of 1 mg/liter associated with stasisd
	CAZe	CAZ-AVI	q2h	q8h	q2h	q8h
11	128	16	45.6	463	19.7	20.9
18	32	2	56.4	151	23.5	16.1

^aConstructed from the data of Berkhout et al. (44).

^bResistance summaries for the strains used in this experiment are as follows. Strain 11: OprD⁻, AmpC^con, class A⁻, class B⁻; strain 18: OprD⁻, AmpC_ind?, class A⁻, class B⁻.

^cAVI, avibactam.

^dStasis-associated exposure times as percentages of the dosing interval calculated to be yielded by the interpolated doses shown.

^eCAZ, ceftazidime.