TABLE 4.

Magnitudes of avibactam exposures associated with stasis and killing of metallo-β-lactamase- and ESBL- and/or CMY-type β-lactamase-coproducing isolates of K. pneumoniae and E. coli in the background of 6-hourly dosing of aztreonam over 24 h in a hollow-fiber model in vitro^a

Strainb	Avibactam %fT>2.5 mg/literc yielding:
	Stasis	1-log10 kill
K. pneumoniae ARC3602	39.3	46.1
K. pneumoniae ARC3803	41.8	44.3
E. coli ARC3600	36.1	40.9
E. coli ARC3805	56.4	58.2
E. coli ARC3807	43.2	48.1
Mean	43.4	47.5
SD	7.8	6.5

^aData were retabulated from Singh et al. (49) with permission from the British Society for Antimicrobial Chemotherapy. ESBL, extended-spectrum β-lactamase.

^bK. pneumoniae ARC3802 omitted because only bacterial responses correlating with an fT>2 mg/liter were reported for that isolate.

^cTimes are expressed as percentages of the 24-h period of the experiment.