TABLE 1.

Activity of SCY-078 against Aspergillus isolates determined by measurement of the MECs and MICs

Species	MEC (μg/ml)			MIC (μg/ml)
				50% inhibition			100% inhibition
	Range	50%	90%	Range	50%	90%	Range	50%	90%
A. flavus (n = 54)	<0.06 to 0.25	<0.06	<0.06	<0.06 to 32	16	16	<0.06 to 32	16	32
A. fumigatus (n = 134)	<0.06 to 4	<0.06	0.125	0.25 to 16	4	8	8 to >32	16	>32
A. niger (n = 27)	<0.06 to 0.5	<0.06	<0.06	<0.06 to 8	2	4	8 to 16	16	16
A. terreus (n = 72)	<0.06 to 0.125	<0.06	0.125	<0.06 to 16	8	8	1 to 16	16	16
Other Aspergillus spp. (n = 24)	<0.06 to 0.25	<0.06	<0.06	<0.06 to 8	2	8	8 to >32	16	32
A. glaucus (n = 5)	<0.06 to 0.125	NDa	ND	1 to 8	ND	ND	32	ND	ND
A. nidulans (n = 9)	<0.06 to 0.125	ND	ND	1 to 4	ND	ND	16 to >32	ND	ND
A. ustus (n = 1)	<0.06	ND	ND	8	ND	ND	16	ND	ND
A. versicolor (n = 8)	<0.06 to 0.25	ND	ND	<0.06 to 8	ND	ND	8 to 32	ND	ND
A. westerdijkiae (n = 1)	<0.06	ND	ND	1	ND	ND	8	ND	ND
All isolates (n = 311)	<0.06 to 4	<0.06	0.125	<0.06 to 32	8	16	<0.06 to >32	16	32

^aND, not determined (MIC₅₀s and MIC₉₀s were not determined due to the low number of isolates of these species tested).