TABLE 2.
Activity of comparators AMB and VOR against Aspergillus isolates determined by measurement of the MICsa
| Species | MIC (μg/ml) |
|||||
|---|---|---|---|---|---|---|
| Amphotericin B |
Voriconazole |
|||||
| Range | 50% | 90% | Range | 50% | 90% | |
| A. flavus (n = 54) | 0.5 to 8 | 4 | 8 | 0.25 to 4 | 1 | 2 |
| A. fumigatus (n = 134) | 1 to >16 | 2 | 4 | 0.25 to >8 | 0.5 | 2 |
| A. niger (n = 27) | 1 to 4 | 1 | 2 | 0.25 to >8 | 1 | 2 |
| A. terreus (n = 72) | 1 to >16 | 8 | 8 | 0.06 to 1 | 0.5 | 1 |
| Other Aspergillus spp. (n = 24) | 1 to >16 | 4 | 16 | 0.125 to 8 | 0.5 | 2 |
| A. glaucus (n = 5) | 1 to 8 | NDb | ND | 0.25 to 2 | ND | ND |
| A. nidulans (n = 9) | 2 to >16 | ND | ND | 0.125 to 1 | ND | ND |
| A. ustus (n = 1) | 4 | ND | ND | 8 | ND | ND |
| A. versicolor (n = 8) | 1 to 16 | ND | ND | <0.063 to 8 | ND | ND |
| A. westerdijkiae (n = 1) | 4 | ND | ND | 0.5 | ND | ND |
| All isolates (n = 311) | 0.5 to >16 | 4 | 8 | 0.6 to >8 | 0.5 | 2 |
a
The MICs were read at the 100% inhibition endpoint.
b
ND, not determined (MIC50s and MIC90s were not determined due to the low number of isolates of these species tested).