TABLE 3.
Activity of SCY-078 plus VOR in combination against A. fumigatus strains by duplicate testing
| MRL strain | MIC (μg/ml) |
FICI | Interpretationa | |||
|---|---|---|---|---|---|---|
| Drug tested alone |
Drug in combination |
|||||
| SCY-078 | VOR | SCY-078 | VOR | |||
| 20438 | 8 | 1 | 0.125 | 0.25 | 0.27 | S |
| 4 | 1 | 0.25 | 0.25 | 0.31 | S | |
| 28378 | 8 | 0.5 | 0.5 | 0.125 | 0.31 | S |
| 4 | 0.25 | 0.5 | 0.016 | 0.19 | S | |
| 28382 | 8 | 0.5 | 0.5 | 0.125 | 0.31 | S |
| 8 | 0.5 | 0.016 | 0.25 | 0.5 | S | |
| 28401 | 8 | 2 | 0.25 | 0.5 | 0.28 | S |
| 8 | 2 | 0.125 | 0.5 | 0.27 | S | |
| 28383b | 8 | >16 | 0.031 | >16 | 1 | NI |
| 8 | >16 | 0.031 | >16 | 1 | NI | |
| 28500b | 4 | >16 | 1 | >16 | 1.25 | NI |
| 8 | >16 | 1 | >16 | 1.13 | NI | |
a
S, synergistic interaction (FICI ≤ 0.5); NI, no interaction (0.5 < FICI ≤ 4.0).
b
Azole-resistant strains.