TABLE 3.
Effect of overexpression of TonB-dependent receptors on siderophore-drug conjugates activities in a piuA deletion mutant of P. aeruginosa
| Strain or plasmid | MIC (mg/liter)a |
||||
|---|---|---|---|---|---|
| BAL | MC-1 | ATM | CFD | CAZ | |
| PAO1ΔpiuA | 8 | 2 | 8 | 8 | 2 |
| pIApX2 (vector) | 8 | 4 | 4 | 8 | 2 |
| ppiuA | 0.25 | 0.03 | 4 | 0.06 | 2 |
| ppirA | 0.25 | 0.06 | 4 | 1–2 | 2 |
| ppiuD | 0.125 | 0.03 | 8 | 0.03–0.125 | 2 |
| ppfuA | 0.03 | 0.03 | 4 | 0.03 | 2 |
| pfptA | 4 | 0.5 | 2 | 0.25 | 2 |
| poptE | 4 | 0.5 | 4 | 2 | 2 |
| poptJ | 4 | 1 | 4 | 4–8 | 2 |
| pfemA | 8 | 2 | 4 | 8 | 2 |
| pPA0151 | 8 | 4 | 2 | 8 | 1 |
a
MIC changes of ≥4-fold compared to the vector control are shown in boldface font. BAL, BAL30072; ATM, aztreonam; CFD, cefiderocol; CAZ, ceftazidime.