TABLE 1.
M. tuberculosis isolates with resistance to the IMP series of molecules
| Compound | Strain identifier | SNP | MIC99 (μM)a |
|---|---|---|---|
| ND-009628 | WTb | NAc | 5.0 |
| ND-009628 | LP-0106906-RM1 | Rv1339 P121L | >100 |
| ND-009628 | LP-0106906-RM2 | Rv1339 S120P | >100 |
| ND-009628 | LP-0106906-RM3 | Rv1339 P121L | 100 |
| ND-008454 | WT | NA | 1.25 |
| ND-008454 | LP-0106898-RM5 | QcrB T313I | >10 |
| ND-008454 | LP-0106898-RM6 | QcrB T313I | >10 |
| ND-008454 | LP-0106898-RM1 | QcrB T313I | >10 |
| ND-009761 | WT | NA | 3.1 |
| ND-009761 | LP-0106908-RM1 | Rv1339 E219K | 12.5 |
| ND-009761 | LP-0106908-RM3 | Rv1339 S119W | 12.5 |
| ND-009761 | LP-0106908-RM4 | Rv1339 T14A | 12.5 |
| ND-009872 | WT | NA | 1.0 |
| ND-009872 | LP-0106909-RM1 | Rv1339 T14A | 5.0 |
| ND-009872 | LP-0106909-RM4 | Rv1339 T14A | 5.0 |
| ND-009872 | LP-0106909-RM5 | Rv1339 T14A | 5.0 |
a
The MIC99s (the minimum concentrations required to prevent 99% of growth) of the indicated compounds were determined on solid medium.
b
WT, wild type.
c
NA, not applicable.