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M. tuberculosis mutant strains are cross-resistant to the IMP series of molecules
| Strain | SNP | MIC99 (μM)a |
|
|---|---|---|---|
| ND-008454 | ND-009872 | ||
| WT | NA | 0.30 | 1.3 |
| LP-0106898-RM5 | QcrB T313I | 10 | >10 |
| LP-0106906-RM1 | Rv1339 P121L | 10 | >10 |
| LP-0106906-RM2 | Rv1339 S120P | 10 | >10 |
| LP-0106908-RM1 | Rv1339 E219K | 10 | >10 |
| LP-0106908-RM3 | Rv1339 S119W | 10 | >10 |
| LP-0106909-RM1 | Rv1339 T14A | 10 | >10 |
The MIC99s of the indicated compounds were determined on solid medium.
