FIG 2.
(A) Killing kinetics of polymyxin B (4 mg/liter as continuous infusion) and enrofloxacin (bolus dose given every 12 h to achieve a Cmax of 3 mg/liter) alone and in combination against P. aeruginosa 12196 in the IVM with an inoculum of ∼108 CFU/ml. Population analysis profiles in the presence of 0.5, 1, 2, 4, and 8 mg/liter polymyxin B at 0 h (baseline) (B), 23 h (C), and 48 h (D) after the first dose. In panel A, lines represent individual fitted viable counts, and marks represent observed viable counts.