FIG 1.

Rhesus macaque and olive baboon θ-defensins. All known θ-defensins are macrocycles exemplified by the ribbon structure of RTD-1 (36). Schematics of the covalent structures of RTDs 1-6 and BTDs 1-10 are listed with the disulfide connectivities and backbone cyclization indicated with solid lines. The 10 gray boxed residues are invariant in all known θ-defensins. Residues in blue are hydrophobic amino acids, Thr residues are in green, and Arg residues in red. The amino acid sequence of Hst 5 is also provided for reference. Net charge is calculated at pH 7.4. MW, molecular weight in kilodaltons. (Republished from reference 36 with permission of the publisher.)