TABLE 1.
MICs of θ-defensins and clinical antifungalsa
| ATCC strain | MIC (μg/ml) |
ATCC phenotype |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RTD |
BTD |
Amp B | Fluco | ||||||||||||||||
| RTD-1 | RTD-2 | RTD-3 | RTD-4 | RTD-5 | BTD-1 | BTD-2 | BTD-3 | BTD-4 | BTD-5 | BTD-7 | BTD-8 | BTD-9 | BTD-10 | Echin | Triazole | 5-Flu | |||
| ATCC 64124 | 6.25 | 6.25 | 12.5 | 12.5 | 12.5 | 6.25 | 6.25 | 12.5 | 25 | 6.25 | 12.5 | 6.25 | 12.5 | 6.25 | 2 | >256 | R | R | I |
| ATCC 10231 | 6.25 | 6.25 | 12.5 | 12.5 | 12.5 | 12.5 | 3.125 | 12.5 | 25 | 6.25 | 12.5 | 6.25 | 12.5 | 6.25 | 2 | 8 | R | R | S |
| ATCC 28121 | 25 | 25 | 12.5 | 12.5 | 12.5 | 25 | 12.5 | 25 | 25 | 12.5 | 12.5 | 6.25 | 12.5 | 6.25 | 4 | 1 | S | R | S |
| ATCC MYA-2876 | 12.5 | 25 | 12.5 | 12.5 | 25 | 25 | 12.5 | 12.5 | 25 | 12.5 | 25 | 12.5 | 12.5 | 12.5 | 4 | 64 | S | S | S |
| ATCC MYA-427 | 12.5 | 12.5 | 25 | 25 | 25 | 25 | 12.5 | 25 | 25 | 12.5 | 25 | 12.5 | 25 | 12.5 | 4 | 128 | S | R | S |
| ATCC MYA-574 | 6.25 | 6.25 | 12.5 | 12.5 | 12.5 | 6.25 | 3.125 | 12.5 | 25 | 6.25 | 12.5 | 3.125 | 12.5 | 3.125 | 2 | >256 | S | R | S |
| ATCC 90819 | 6.25 | 6.25 | 12.5 | 12.5 | 12.5 | 6.25 | 3.125 | 12.5 | 25 | 6.25 | 12.5 | 6.25 | 12.5 | 6.25 | 2 | >256 | S | R | S |
| ATCC MYA-1023 | 12.5 | 6.25 | 25 | 12.5 | 12.5 | 12.5 | 6.25 | 25 | 25 | 12.5 | 12.5 | 12.5 | 12.5 | 6.25 | 2 | 32 | S | R | S |
| ATCC 76485 | 12.5 | 6.25 | 12.5 | 12.5 | 12.5 | 12.5 | 1.56 | 25 | 25 | 12.5 | 12.5 | 6.25 | 12.5 | 6.25 | 2 | 128 | R | S | S |
| ATCC 38289 | 12.5 | 12.5 | 25 | 25 | 25 | 12.5 | 12.5 | 25 | 25 | 12.5 | 25 | 12.5 | 25 | 6.25 | 4 | >256 | S | R | S |
| ATCC 11651 | 12.5 | 12.5 | 25 | 25 | 25 | 12.5 | 6.25 | 25 | 25 | 12.5 | 25 | 12.5 | 12.5 | 12.5 | 4 | >256 | S | R | S |
| ATCC 96901 | 12.5 | 6.25 | 25 | 25 | 25 | 25 | 6.25 | 25 | 25 | 12.5 | 25 | 25 | 25 | 12.5 | 4 | 1 | S | R | S |
| ATCC 90029 | 12.5 | 12.5 | 12.5 | 25 | 12.5 | 12.5 | 6.25 | 12.5 | 25 | 12.5 | 12.5 | 12.5 | 12.5 | 12.5 | 4 | 1 | S | S | R |
| ATCC 18804 | 6.25 | 6.25 | 12.5 | 12.5 | 25 | 12.5 | 6.25 | 25 | 25 | 12.5 | 12.5 | 12.5 | 12.5 | 6.25 | 2 | 1 | S | S | S |
a
CLSI protocol was used to determine MICs for each θ-defensin and amphotericin B (Amp B) and fluconazole (Fluco). ATCC phenotypes (S, susceptible; R, resistant; I, intermediate) are reported for one or more echinocandin (Echin), triazole, or 5-flucytosine (5-Flu).