TABLE 4.
MFCs of θ-defensins and clinical antifungalsa
| Candida CDC strain | MFC (μg/ml) |
CDC phenotype |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| RTD |
BTD |
Fluco | Caspo | ||||||
| RTD-1 | RTD-2 | BTD-2 | BTD-4 | BTD-8 | Caspo | Fluco | |||
| C. glabrata 0314 | 6.25 | 3.125 | 3.125 | 12.5 | 6.25 | 128 | 1 | R | R |
| C. glabrata 0316 | 6.25 | 3.125 | 1.56 | 12.5 | 6.25 | 8 | 2 | R | SDD |
| C. parapsilosis 0335 | 6.25 | 6.25 | 3.125 | >25 | 6.25 | 16 | 1 | I | R |
| C. parapsilosis 0337 | 6.25 | 6.25 | 3.125 | 25 | 6.25 | 128 | 1 | S | R |
| C. tropicalis 0345 | 3.125 | 1.56 | 1.56 | 25 | 1.56 | >256 | 0.125 | S | R |
| C. krusei 0397 | 3.125 | 3.125 | 1.56 | 12.5 | 3.125 | 256 | 1 | S | R |
| C. auris 0384 | 12.5 | 6.25 | 6.25 | >25 | 6.25 | >256 | >8 | NA | NA |
| C. auris 0389 | 12.5 | 6.25 | 6.25 | >25 | 6.25 | >256 | >8 | NA | NA |
a
MFC assays were conducted as described in Materials and Methods. MFC values correspond to 99% killing relative to input inoculum. Abbreviations are the same as listed in Table 3.