Table 2: Use of Cardiovascular Medications and Devices in Patients with HFmrEF as Reported in Recent Analyses of Data from Clinical Registries.
| SwedeHF[11] | GWTG-HF[20] | CHART-2[13] | TIME-CHF[24] | MUSIC/REDINSCOR I[23] | REDINSCOR II[22] | RICA[21] | |
|---|---|---|---|---|---|---|---|
| ACEi/ARB (%) | 84 | 64.7‡ | 80.0 | 90.7 | 87.2 | 72.4‡ | 79 |
| Beta-blockers (%) | 86 | 78.5‡ | 63.8 | 73.1 | 76.7 | 71.8‡ | 71.0 |
| MRAS (%) | 24 | 11.9‡ | 29.3 | 33.3 | 40.0 | 45.0‡ | 41.0 |
| ARNI (%) | NA | NA | NA | NA | NA | NA | NA |
| Ivabradine (%) | NA | NA | NA | NA | NA | NA | 1.0 |
| Diuretics (%) | 74 | 46.5‡ | 63.3 | NA | NA | NA | NA |
| Loop diuretics (%) | NA | NA | NA | 89.8 | 76.7 | NA | 93.0 |
| Thiazides (%) | NA | NA | NA | NA | NA | NA | 14.0 |
| Digoxin (%) | 16 | 14.8‡ | NA | 13.9 | 16.8 | NA | 25.0 |
| Anticoagulation therapy (%) | 38 | 31.9‡ | NA | NA | NA | NA | 53.0 |
| Statins (%) | 48 | 55.4* | 39.6 | NA | 59.1 | NA | NA |
| Platelet inhibitors (%) | 53 | 45.4† | 27.0§ | NA | 30.2 | NA | 41.0 |
| Nitrates (%) | 17 | 18.4† | NA | 32.4 | NA | NA | NA |
| CRT (%) | 0.9 | 11.5 | 1.8 | NA | 4.6 | NA | NA |
| ICD (%) | 1.3 | 3.9 | 3.9 | 2.8 | 7.0 | NA | NA |
| Vasodilators (%) | NA | 15.8‡ | NA | NA | NA | NA | 29.0 |
*Lipid-lowering medications; †on admission; ‡discharge medication; §aspirin; ACEi = angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI = angiotensin receptor nepriiysin inhibitor; CHART-2 = Chronic Heart Failure Analysis and Registry in the Tohoku District-2 Study; CHF = trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure; CRT = cardiac resynchronisation therapy; GWTG-HF = The Get With The Guidellnes-HF Registry; HFmrEF = heart faiiure with mid-range ejection fraction; ICD = implantable cardioverter-defibrillator; MRA = mineralocorticoid receptor antagonist; NA = data not avaiiable; REDINSCOR II – Red Espan'ola de Insuficiencia Cardiaca researchers; RICA – Spanish National Registry on Heart Failure; SwedeHF = Swedish Heart Failure Registry; TIME-MUSIC/REDINSCORI – MUerte Subita en Insuficiencia Cardiaca/Network for the Study of Heart Failure.