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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Eur J Pharmacol. 2018 Mar 3;828:9–17. doi: 10.1016/j.ejphar.2018.02.045

Fig 5.

Fig 5

Left – 1H HRMAS spectra averaged from all animals in each group of 5xFAD mice with (n=9) and without (n=8) 7,8-DHF supplementation. The spectra are normalized to the creatine (Cr) peak. The spectra are quite similar but increases in choline (Cho) can be seen in the 5xFAD spectrum compared to the 5xFAD + 7,8-DHF spectrum. Right – Expansions of three representative spectra from the “cholines” region (shown in blue on the left spectra) showing the increased Cho in the 5xFAD animal. These spectra were also normalized to the Cr peak. The separation between glycerophosphocholine (GPC) and phosphocholine (PhC) is small enough that it is blurred in the averaged spectra shown on the left, but is readily apparent in individual spectra.