Table I.
Summary of Changes in Peptide Transport Across the BBB in Obesity
| Peptide | BBB transport direction change due to obesity | Approximate change compared to lean | Model | Reference |
|---|---|---|---|---|
| Leptin | Decreased | 76% | Humans | (69) |
| 80% | Humans | (70) | ||
| 24% | Sheep | (71) | ||
| 69% | Mice | (72) | ||
| Insulin | Decreased | 45% | Humans | (73) |
| 45% | Dogs | (74) | ||
| 55% | Zucker rat | (75) | ||
| 54% | Mice | (76) | ||
| Adiponectin | Not investigated | No BBB transport | Humans | (77) |
| No BBB transport | Mice | (78) | ||
| Ghrelin | Decreased | 96% | Mice | (79) |
| FFA | Increased | 50% | Humans | (80) |
| Palmitate | Increased | 86% | Humans | (80) |
| Amylin | Not investigated | |||
| GLP-1 | Not investigated |
BBB blood-brain barrier, FFA free fatty acids, GLP-1 glucagon-like peptide-1