Table 2.
Personalizing Insomnia Therapies for Patients with Psychiatric Disorders
| Condition Associated with Insomnia | Most-Specific Agents Suited for Use |
Non-Specific Agents Best- Suited for Use |
|---|---|---|
| Generalized Anxiety Disorder | Suvorexant (theoretical basis) | Eszopiclone |
| Post-Traumatic Stress Disorder | Prazosin | |
| Major Depression | Eszopiclone | |
| Substance Dependence/Discontinuation | Suvorexant (theoretical basis) | |
| Psychosis | Antipsychotic | |
| Any Condition Associated Only with Early Morning Awakening or Early Morning Awaking and Sleep Maintenance Difficulty | Doxepin 3–6 mg | |
| Any Condition Associated Only with Problems Falling Asleep | Ramelteon/Melatonin | Zolpidem/Zaleplon |
| Any Condition Associated with Problems Falling Asleep and Staying Asleep | Suvorexant | Eszopiclone, Zolpidem Extended Release |
| Delayed Sleep Phase Syndrome | Melatonin | |
| Autism and Other Neurodevelopmental Disorders | Melatonin |