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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Mol Psychiatry. 2017 Nov 28;23(10):2057–2065. doi: 10.1038/mp.2017.230

Figure 1.

Figure 1

PV neurons and WFA/PNNs are decreased in the TRN of subjects with SZ and BD. (a) Total number and Nd of PV neurons in the TRN of healthy subjects, SZ and BD subjects. Marked decreases were observed in each disorder with respect to healthy controls. SZ: PV neurons - Tn: p < 0.0001, Hedges’ g = −2.08, 71.1% decrease; Nd: p < 0.0001, Hedges’ g= −2.09, 66.4% decrease; BD: PV neurons - Tn: p < 0.0007, Hedges’ g = −1.88, 72.1% decrease; Nd: p < 0.003, Hedges’ g= −1.55, 55.9% decrease. (b) Example of a PV neuron in the TRN of a healthy human subject. (c) Total number and Nd of WFA/PNNs in the TRN of healthy subjects, SZ and BD subjects. Significant decreases were observed in each disorder with respect to healthy controls. SZ: WFA/PNNs - Tn: p < 0.006, Hedges’ g = −1.40, 81.3% decrease; Nd: p < 0.003, Hedges’ g= −1.52, 67.2% decrease; BD: (WFA/PNNs - Tn: p < 0.04, Hedges’ g = −0.77, 57.1% decrease; Nd: p < 0.001, Hedges’ g= −0.92, 51.9% decrease). (d) Example of WFA/PNNs in the healthy human TRN. Note that all bar graphs show logarithmically transformed values and do not reflect the effects of confounding variables included in ANCOVA models.