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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Semin Cancer Biol. 2017 Nov 28;52(Pt 2):53–65. doi: 10.1016/j.semcancer.2017.11.009

Figure 3. The lncUSMycN act by inhibiting degradation of N-Myc mRNA.

Figure 3

[A] In normal, cell, N-Myc undergoes degradation at post transcriptional and post translation level. [B] In neuroblastoma cells, MYCN oncogene harbor lncUSMycn, a lncRNA at 14 kb upstream of the gene. The lncUSMycn act as a scaffold for the RNA binding protein NonO. This facilitate the interaction between NonO and MYCN. This results in the stabilization of MYCN transcript and eventually proliferation of tumor cells