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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Semin Cancer Biol. 2017 Nov 28;52(Pt 2):53–65. doi: 10.1016/j.semcancer.2017.11.009

Table 2.

A list of lncRNAs dys-regulated in neuroblastoma and their functions

Column1 Column2 Column3 Column4
lncRNA Expression Function/Clinical
implication		 Reference
linc00467 - Reduced neuroblastoma growth through modulation of DKK1 [140]
SNHG1 Associated with event-free survival of patients [141]
GAS5 Regulated expression of p53, BRCA1, and GADD45A in neuroblastoma cells [142]
MALAT1 Induced migration and invasion of neuroblastoma cells [143]
MALAT1 Modulated cell migration, invasion and vasculature formation by down-regulating FGF2 in [144]
neuroblastoma cells under hypoxic conditions
MALAT1 Up-regulated Axl and induced invasion and migration of neuroblastoma cells [145]
MALAT1 Induced ERK/MAPK activation and neuronal differentiation in neuroblastoma cell lines [146]
HCN3 Regulated apoptosis and proliferation in neuroblastoma cells [147]
linc01105 Regulated apoptosis and proliferation in neuroblastoma cells [147]
MEG3 ↓ Regulated apoptosis and proliferation in neuroblastoma cells [147]
NBAT1 ↓ Regulated proliferation and invasion of neuroblastoma cells by interacting with EZH2; [148]
associated with poor clinical outcome in patients
NBAT1 ↓ Contributed to the aggressiveness of neuroblastoma by promoting proliferation and [21]
an impairment of differentiation of neuronal precursors
CASC15 ↓ Regulated extracellular matrix transcripts, adhesion, growth, and migration of neuroblastoma cells [150]
ncRAN Associated with poor prognosis of neuroblastoma patients [151]
Dali - Regulated the differentiation of neuroblastoma cells [152]
PVT-1 Regulated expression of Myc proteins [153]
CAI2 Associated with high-risk and clinical outcome of neuroblastoma patients [161]
lncUSMycN - Regulated N-Myc expression and neuroblastoma oncogenesis in mice model [162]
lncUSMycN Induced NCYM expression; correlated with poor prognosis of neuroblastoma patients [163]
HOXD-AS1 - Regulated RA-induced differentiation and oncogenesis in mice model expression of genes associated [164]
with angiogenesis and inflammation in SH-SY5Y neuroblastoma cells
Paupar - Induced differentiation of neuroblastoma cells [166]

Abbreviations: -: up-regulation, ¯: down-regulation, Axl: AXL receptor tyrosine kinase, BRCA1: breast cancer 1, DKK1: dickkopf WNT signaling pathway inhibitor 1, ERK: extracellular signal-regulated kinase, MAPK: mitogen-activated protein kinase, EZH2: enhancer of zeste homolog 2, FGF2: fibroblast growth factor 2, GADD45A: growth arrest and DNA damage-inducible protein 45 alpha, Myc: myelocytomatosis oncogene, NBAT1: neuroblastoma associated Transcript 1, RA, retinoid acid