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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2018 Mar 27;27(7):1743–1751. doi: 10.1016/j.jstrokecerebrovasdis.2018.01.030

Figure 3. There is decreased white matter injury in the corpus callosum in BCAS and sham mice who receive oral estradiol.

Figure 3

One day after behavior testing the brains from male mice were fixed, sliced, and prepared for Klüver-Barerra staining (left side, representative sections) to assess the changes to white matter tracks of the corpus callosum. Analysis using a white matter injury scale (right side; see methods for injury scale ranking) shows that the oral estradiol treated BCAS group had decreased white matter injury compared to the placebo counterpart. Estradiol-treated sham animals also demonstrated less white matter injury than their placebo treated counterparts. *p < 0.05, **p < 0.01 (unpaired two tailed t-test comparisons are between P and E2 groups within each treatment cohort)