Skip to main content
. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Pain. 2018 Jan 31;19(6):626–634. doi: 10.1016/j.jpain.2018.01.003

Fig 1. Gasserian ganglion microinjection of ZD7288 reduced nociceptive behavior in dIoN-CCI rats.

Fig 1

(A, B) dIoN-CCI induced mechanical allodynia and intense unilateral facial grooming, which lasted for weeks in rats (sham vs dIoN-CCI. *P<0.05, n = 6). (C, D) Infusion of 0.1 μg of ZD7288 to the GG site ipsilateral to the dIoN-CCI side transiently reduced mechanical allodynia measured at 30 min after drug administration. (E, F) Microinjection of 1μg of ZD7288 to the ipsilateral side of the GG reduced mechanical allodynia for at least 60 min. Facial grooming was also significantly reduced in dIoN-CCI rats. (before vs. after ZD7288 infusion * p<0.05, n = 6).