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. 2018 May 29;4:26. doi: 10.1038/s41421-018-0024-3

Fig. 4. PEAK1 regulates the expression of multiple pro-angiogenic factors in human ECs.

Fig. 4

a Volcano plot for quantitative multiplexed proteomics revealed 5565 proteins across all HUVECs samples treated with siCtrl or siPEAK1 (Also see Supplementary Table S4). A total of 103 proteins were significantly up-regulated while 63 proteins were significantly down-regulated in the siPEAK1 samples relative to the siCtrl samples, (n = 3, p < 0.05, fold-change ≥1.5, dark dots, also see Supplementary Table S5). b Bar graph represents the normalized summed S/N value of VEGFR2 (Left) or PEAK1 (Right) protein level identified by multiplexed proteomics. Mean ± SEM; n = 3; **P < 0.003; *P < 0.02. c Protein network analysis using STRING10.0 of downregulated proteins in HUVECs by PEAK1 depletion from quantitative multiplex proteomic analysis. Proteins with known or predicted functions in vascular development or angiogenesis are highlighted (Red ball)