Table 3.
Cox proportional regression for prognostic factors of 90-day mortality in methicillin-sensitive Staphylococcus aureus bacteremia patients aged ≥ 60 years (n = 286)
| Patient characteristics | Outcome | Univariate analysis | Cox regression | |||
|---|---|---|---|---|---|---|
| Died n = 78 (27) |
Survived n = 208 (73) |
OR (95% CI) | p value | HR (95% CI) | p value | |
| Male sex | 46 (59) | 121 (58) | 1.03 (0.61–1.75) | NS | – | – |
| Healthcare-acquired | 48 (62) | 128 (62) | 1.00 (0.59–1.71) | NS | – | – |
| Healthy—nonfatala | 29 (37) | 143 (69) | 0.27 (0.16–0.46) | < 0.001 | 0.38 (0.24–0.61) | < 0.001 |
| Severe sepsisb | 12 (15) | 14 (7) | 2.52 (1.11–5.72) | 0.023 | 1.98 (1.04–3.79) | 0.039 |
| Formal ISCc | 61 (78) | 189 (91) | 0.36 (0.18–0.74) | 0.004 | 0.45 (0.26–0.78) | 0.004 |
| Endocarditis | 18 (23) | 23 (11) | 2.41 (1.22–4.77) | 0.01 | 2.09 (1.19–3.64) | 0.01 |
| Pneumonia | 49 (63) | 62 (30) | 3.98 (2.30–6.88) | < 0.001 | 2.58 (1.59–4.18) | < 0.001 |
| Rifampicind,e | 20 (26) | 110 (53) | 0.31 (0.17–0.55) | < 0.001 | 0.32 (0.19–0.54) | < 0.001 |
| Fluoroquinoloned | 35 (45) | 105 (50) | 0.79 (0.47–1.35) | NS | – | – |
Values are expressed as number of patients (%) and odds ratios (OR), hazards ratio (HR) and 95% confidence intervals (95% CI) are presented
NS non-significant
aMcCabe’s classification [20]
bAt blood culture collection time-point
cInfectious specialist consultation
dAdjunctive therapy
eFor at least 14 days