Table 1.
Paracellular tightness of different brain endothelial and epithelial cell culture models measured by transendothelial/epithelial electrical resistance (TEER) and permeability for markers fluorescein and albumin.
| Models | TEER (Ω × cm2) | Fluorescein Papp (10−6 cm/s) | Albumin Papp (10−6 cm/s) |
|---|---|---|---|
| EPA | 475 ± 48 | 2.1 ± 0.25 | 0.2 ± 0.03 |
| CaCo2 | 854 ± 24 | 1.5 ± 0.28 | 0.8 ± 0.09 |
| VB-CaCo2 | 1186 ± 71 | 0.3 ± 0.06 | 0.2 ± 0.08 |
| MDCK | 72 ± 9 | 2.8 ± 0.23 | 0.6 ± 0.05 |
| MDCK-MDR1 | 81 ± 7 | 2.7 ± 0.31 | - |
| GP8 | 28 ± 13 | 39.8 ± 3.51 | 16.5 ± 7.51 |
| RBE4 | 64 ± 5 | 27.4 ± 1.63 | 3.9 ± 0.23 |
| D3 | 45 ± 2 | 22.2 ± 3.71 | 2.1 ± 0.31 |
| D3L | 86 ± 6 | 19.3 ± 1.22 | 1.7 ±0.12 |
Papp: apparent permeability coefficients. Values are presented as mean ± SD.