Table 3.

Noise reduction algorithm for 2D visualization.

Noise reduction step of algorithm 2D	Function	Settings	Timing (s)
1	Image loading	−	9
2	Histogram transform	reference image	648
3	Guided filter	r = 1, ε = 1	810
4	Bilateral filter	σ = 1, μ = 0.00017	22,212
5	Guided filter	r = 1, ε = 1	810
6	Sharpen	–	969

A single chosen slide functions as rreference image, to equalize contrast in the Z axis. Total processing time for sample S1 is 25,438 s. Function names correspond to function names in Wolfram Mathematica.