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. 2018 May 22;9:535. doi: 10.3389/fphar.2018.00535

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Copyright © 2018 Yin, Deng, Zhao and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tree representation of the data. (A) The tree with sequential structure. (B) The tree with trellis-like structure (alternative version of the A). Each circle stands for single drug-dose or combination. Letter and number indicates drug and dose, respectively. For a tree, level 0 is the control (no drug), level 1 is composed of individual drug treatment with two doses, and level 2 is composed of drug-dose combinations. The level depends on the size of the combination.