Table 1.
Classification of autophagy from the view of inducers and substrates.
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Bulk autophagy (non-specific degradation) | Selective autophagy (specific degradation) |
---|---|---|
Constitutive autophagy (maintain homeostasis) |
Cellular metabolism Replace old proteins/organelles with new ones |
Cell protection Degrade unfavorable, damaged proteins, and organelles |
Inducible autophagy (response to various stimuli) |
Nutrient supply Starvation-induced Rapamycin-activated |
Cellular adaptation Cellular stress (DNA damage, etc.) Differentiation |