Table 2.

Diagnostic value of the human papillomavirus (HPV) E6/E7 oncoprotein test, Hybrid Capture 2 (HC2) HPV DNA test, and ThinPrep cytological test (TCT) for high-grade cervical lesions (CIN2+).

Diagnostic tests	Sensitivity	Specificity	PPV	NPV
HPV E6/E7	65.5 (60.5, 70.5)	38.2 (28.6, 47.8)	78.4 (73.6, 83.1)	24.5 (17.8, 31.3)
HC2	96.6 (94.6, 98.5)	5.9 (1.2, 10.5)	77.8 (73.8, 81.7)	33.3 (9.2, 57.5)
TCT	36.2 (31.1, 41.3)	88.2 (81.2, 94.6)	91.3 (86.5, 96.1)	28.8 (23.8, 33.9)

Data presented as percentage (95% confidence interval).

PPV, positive predictive value; NPV, negative predictive value.

Sensitivity = true positive/(true positive + false negative); specificity = true negative/(true negative + false positive); PPV = true positive/(true positive + false positive); NPV = true negative/(true negative + false negative).