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. 2018 May 22;9:431. doi: 10.3389/fphar.2018.00431

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Copyright © 2018 Insel, Sriram, Wiley, Wilderman, Katakia, McCann, Yokouchi, Zhang, Corriden, Liu, Feigin, French, Lowy and Murray.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPCR expression in B-CLL cells. (A) Venn diagram showing the number of GPCRs expressed in B-CLL cells (I1, I2, and I3) isolated from three different patients with indolent CLL. I1, I2, and I3, expressed 142, 162, and 147 GPCRs, respectively, and shared in expression of 106 GPCRs. (B) G protein linkages of the 106 commonly expressed GPCRs. (C) The expression (ΔCt normalized to 18S rRNA) and fold-increase in expression in indolent CLL cells compared to control B cells of the four GPCRs (GABBR1, CNR2, CELSR1, and GPR92) with approximately twofold (or greater) increases in expression in the CLL cells. n = 3 biological replicates of B-CLL, analyzed on one array each.