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. 2018 May 22;9:431. doi: 10.3389/fphar.2018.00431

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Copyright © 2018 Insel, Sriram, Wiley, Wilderman, Katakia, McCann, Yokouchi, Zhang, Corriden, Liu, Feigin, French, Lowy and Murray.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPCR expression in pancreatic cancer tumors. (A) Venn diagram of GPCR expression, determined using Taqman GPCR arrays, of three PDAC tumor samples with 77 GPCRs commonly detected among the samples. T1424, T1255, and T760 expressed 185, 175, and 145 GPCRs, respectively. (B) G-protein linkage of the 77 commonly detected GPCRs. (C) GPRC5A is expressed at similar levels in PDAC cells and tumors. The highest expressed GPCRs in cancer cells were also highly expressed in tumors. n = 3 primary tumors, each assayed on one array each.