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. 2018 May 22;9:1095. doi: 10.3389/fimmu.2018.01095

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Copyright © 2018 Xiao, Chen, He and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of CXCR5⁺CD8 T cells in lymphocytic choromeningitis virus (LCMV)-Cl13 and human immunodeficiency virus (HIV) infection. In chronic LCMV-Cl13 infection, viruses seldom infect B-cell follicles, thus B-cell follicles function as a sanctuary for CXCR5⁺CD8 T cells to prevent rapid exhaustion. In contrast, HIV virus preferentially targets TFH cells in B-cell follicles for productive and latent infection, thus accumulating high antigen loads in B-cell follicles may drive more severe exhaustion of CXCR5⁺CD8 T cells.