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. 2018 May 22;9:579. doi: 10.3389/fphys.2018.00579

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Copyright © 2018 Pottecher, Adamopoulos, Lejay, Bouitbir, Charles, Meyer, Singer, Wolff, Diemunsch, Laverny, Metzger and Geny.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hematoxylin-eosin staining of gastrocnemius muscles from sham-operated, vehicle-treated (nCON) and streptozotocin-treated rats (dCON), and after ischemia reperfusion in vehicle-treated (nIR) and streptozotocin-treated rats (dIR). Magnification ×400. Compared to nCON, gastrocnemius muscles from dCON rats showed reduced muscle fiber diameter, increased number of inflammatory cells invading the intercellular space (thin black, swept arrowheads) and intercellular edema (large black, solid arrowheads). After IR, gastrocnemius muscles from the nIR group displayed both increased intercellular and intracellular edema (large gray, solid arrowheads). After IR, gastrocnemius from the dIR group showed totally distorted anatomy with extensive necrosis and cell lysis surrounded by clusters of inflammatory cells (thin black, swept arrowheads).