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. 2018 May 22;9:528. doi: 10.3389/fphar.2018.00528

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Copyright © 2018 Moreira, Silva, Silva, Lemos and Cortes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cyclooxygenase 1 and 2, phosphatidylinositol 3-kinase, and transient receptor potential channels are not involved in the vasodilator effect of D-pinitol in mice mesenteric arteries. The concentration-dependent vasodilator effect of D-pinitol was investigated in mesenteric arteries with a functional endothelium in the absence (Control) and presence of indomethacin (A), celecoxib (B), wortmannin (C), and ruthenium red (D). All results are expressed as mean ± SEM of five experiments.