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. 2018 May 22;9:528. doi: 10.3389/fphar.2018.00528

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Copyright © 2018 Moreira, Silva, Silva, Lemos and Cortes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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D-pinitol increases the formation of nitrite through a mechanism dependent on the activation of endothelial nitric oxide synthase (eNOS) by the calcium-calmodulin complex. The formation of nitrite was measured in endothelium-intact mesenteric arteries in the absence (basal) or presence of D-pinitol (control/ A) or acetylcholine (ACh; control; B). The involvement of eNOS and calmodulin was evaluated in mesenteric arteries stimulated with D-pinitol or ACh in the presence of L-NAME and calmidazolium, respectively. All results are expressed as mean ± SEM of five experiments. ^∗∗∗P < 0.001 versus basal. ^†P < 0.05, and ^†††P < 0.001 versus control.