Figure 2.

Phylogenetic tree analyses of the RING-domain E3 ligases (RING E3s). Several examples of each type of RING E3s are shown. Each family has its special structure besides the conserved RING domain, which is shown as tawny. For tripartite motif-containing (TRIM) family, two B-box domains (BB), coiled-coiled domain (CC) are colored with dark blue and light blue, respectively. For membrane-associated RING-CH (MARCH) family, transmembrane (TM) domain is pink colored. For PA-TM-RING family, the protease-associated (PA) domain and two TM domains are colored orange and pink, respectively. For RING between RING (RBR) family, in-between-RING (IBR) domain is green colored. For RING-ubiquitin interacting motif (UIM) family, a C₂HC-type zinc finger, two C₂H₂-type zinc fingers, and UIM are colored dark purple, light purple, and brown, respectively. Phylogenetic analysis was performed using MEGA6.