Figure 3.

Relationships among maternal toenail inorganic arsenic (iAs) levels, prenatal peripheral blood metabolites, and cord blood iAs levels. Prenatal toenail iAs exposure (log_e scale) during the first trimester of pregnancy had a significant correlation with the cord blood arsenic level evaluated by Pearson correlation (r), and linear regression (coefficient β and P). Two maternal peripheral blood serum metabolites, butyrylqlycine (M₁) and tartarate (M₂) at the second trimester were associated with lower cord blood iAs levels evaluated by linear regression with adjustment for prenatal toenail iAs levels, as well as their interaction effect.