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. Author manuscript; available in PMC: 2018 May 29.
Published in final edited form as: Immunol Rev. 2013 Sep;255(1):25–39. doi: 10.1111/imr.12101

Figure 1. Type I IFN signaling pathways.

Figure 1

All known IFN signaling pathways are initiated by Jak kinase tyrosine phosphorylation of substrate proteins. In the canonical Jak-STAT pathway (pink), Jak kinases phosphorylate STAT1 and STAT2 promoting formation of ISGF3. Phosphorylation of STAT1, 3, 4 and 5 also generates pSTAT homo- and heterodimers (SIFs). Activation of the MAPK-p38 pathway (yellow) is initiated by phosphorylation of vav or another GEF. Activation of PI3K pathways (blue), including mTOR is initiated by phosphorylation of IRS1/2.