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. Author manuscript; available in PMC: 2018 May 29.
Published in final edited form as: Biol Psychiatry. 2015 Dec 19;80(11):836–848. doi: 10.1016/j.biopsych.2015.12.012

Fig. 5.

Fig. 5

AC3 KO mice exhibit deficits in spatial navigation and suppressed Long-lasting LTP (L-LTP). (A) Learning curve for the hidden platform test in the Morris water maze. Data are averages of 3 trials each day. (B) Time in each quadrant during the probe test. Inset: representative swimming pattern during the probe test. (C) Number of target site crossings during the probe test. (D–E) Suppressed L-LTP in mice. Decremental LTP (D-LTP) was induced with one train of tetanus stimulation (D), while L-LTP was induced by 4 trains of tetanus stimulation (E). Top insets: representative field EPSPs before and at 60 min (D-LTP) or at 150 min (L-LTP) after LTP induction. D-LTP of AC3 KO mice was comparable to AC3 WT mice, (Two-way ANOVA test comparing data points of last 10 min, genotype effect, F (1, 117) = 0.53, p=0.48), while L-LTP was attenuated in AC3 KO mice (Two-way ANOVA test comparing data of last 20 min, genotype effect, F (1, 216) = 101, p<0.0001).