Table 4.
New proteins found in present microglia-derived EV samples
| Protein ID | Gene name | Protein name |
|---|---|---|
| P08226 | APOE | Apolipoprotein E |
| P21460 | CST3 | Cystatin-C |
| Q8VDN2 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 |
| P62737 | ACTA2 | Actin, aortic smooth muscle |
| Q61753 | PHGDH | D-3-phosphoglycerate dehydrogenase |
| P10605 | CTSB | Cathepsin B |
| P01942 | HBA | Hemoglobin subunit alpha |
| Q62419 | SH3GL1 | Endophilin-A2 |
| Q8R366 | IGSF8 | Immunoglobulin superfamily member 8 |
| Q68FD5 | CLTC | Clathrin heavy chain 1 |
| P10923 | SPP1 | Osteopontin |
| Q61207 | PSAP | Prosaposin |
| P06869 | PLAU | Urokinase-type plasminogen activator |
| Q8CGP5 | HIST1H2AF | Histone H2A type 1-F |
| P04104 | KRT1 | Keratin, type II cytoskeletal 1 |
| P68369 | TUBA1A | Tubulin alpha-1A chain |
| P01887 | B2M | Beta-2-microglobulin |
| P09405 | NCL | Nucleolin |
| P09055 | ITGB1 | Integrin beta-1 |
| P01901 | H2-K1 | H-2 class I histocompatibility antigen, K-B alpha chain |
| P01899 | H2-D1 | H-2 class I histocompatibility antigen, D-B alpha chain |
| P29341 | PABPC1 | Polyadenylate-binding protein 1 |
| P06797 | CTSL | Cathepsin L1 |
| P10852 | SLC3A2 | 4F2 cell-surface antigen heavy chain |
| P08905 | LYZ2 | Lysozyme C-2 |
| P10126 | EEF1A1 | Elongation factor 1-alpha 1 |
| Q61937 | NPM1 | Nucleophosmin |
| P28798 | GRN | Granulins |
| P14206 | RPSA | 40S ribosomal protein SA |
| P68372 | TUBB4B | Tubulin beta-4B chain |
| P62242 | RPS8 | 40S ribosomal protein S8 |
| P47963 | RPL13 | 60S ribosomal protein L13 |
| Q9CZX8 | RPS19 | 40S ribosomal protein S19 |
| P15864 | HIST1H1C | Histone H1.2 |
| Q8VEK3 | HNRNPU | Heterogeneous nuclear ribonucleoprotein U |
| Q9CR57 | RPL14 | 60S ribosomal protein L14 |
| P63276 | RPS17 | 40S ribosomal protein S17 |
| P62082 | RPS7 | 40S ribosomal protein S7 |
| Q9D8E6 | RPL4 | 60S ribosomal protein L4 |
| P35979 | RPL12 | 60S ribosomal protein L12 |
| P14131 | RPS16 | 40S ribosomal protein S16 |
| P70696 | HIST1H2BA | Histone H2B type 1-A |
| P12970 | RPL7A | 60S ribosomal protein L7a |
| P60710 | ACTB | Actin, cytoplasmic 1 |
| Q9CXW4 | RPL11 | 60S ribosomal protein L11 |
| Q9CZM2 | RPL15 | 60S ribosomal protein L15 |
| P02301 | H3F3C | Histone H3.3C |
| P47911 | RPL6 | 60S ribosomal protein L6 |
| P43276 | HIST1H1B | Histone H1.5 |
| Q8CGP5 | HIST1H2AF | Histone H2A type 1-F |
| P14115 | RPL27A | 60S ribosomal protein L27a |
| P27659 | RPL3 | 60S ribosomal protein L3 |
| O55142 | RPL35A | 60S ribosomal protein L35a |
| P25206 | MCM3 | DNA replication licensing factor MCM3 |
| P62702 | RPS4X | 40S ribosomal protein S4, X isoform |
| P10126 | EEF1A1 | Elongation factor 1-alpha 1 |
| Q8BP67 | RPL24 | 60S ribosomal protein L24 |
| P14206 | RPSA | 40S ribosomal protein SA |
| P11499 | HSP90AB1 | Heat shock protein HSP 90-beta |
| P08226 | APOE | Apolipoprotein E |
| P35980 | RPL18 | 60S ribosomal protein L18 |
| P63017 | HSPA8 | Heat shock protein 8 |
| P80318 | CCT3 | T-complex protein 1 subunit gamma |
| P62918 | RPL8 | 60S ribosomal protein L8 |
| P62911 | RPL32 | 60S ribosomal protein L32 |
| P14869 | RPLP0 | 60S acidic ribosomal protein P0 |
| Q9JIK5 | DDX21 | Nucleolar RNA helicase 2 |
| P62281 | RPS11 | 40S ribosomal protein S11 |
| P62717 | RPL18A | 60S ribosomal protein L18a |
| P86048 | RPL10L | 60S ribosomal protein L10-like |
| P62267 | RPS23 | 40S ribosomal protein S23 |
| P25444 | RPS2 | 40S ribosomal protein S2 |
| P14148 | RPL7 | 60S ribosomal protein L7 |
| P53026 | RPL10A | 60S ribosomal protein L10a |
| P62264 | RPS14 | 40S ribosomal protein S14 |
| P62908 | RPS3 | 40S ribosomal protein S3 |
| P04918 | SAA3 | Serum amyloid A-3 protein |
Proteins identified in present study were compared with proteins uploaded in Exocarta database from microglial origin. Protein ID and gene name are according to Uniprot Knowledgebase