Table 1.
Baseline characteristics and pulmonary function parameters by study group
| Characteristic | COPD (N = 17) | NOS (N = 16) | NS (N = 13) | p-value |
|---|---|---|---|---|
| Male gender, n (%) | 15 (88) | 16 (100) | 5 (38) | < 0.001 |
| Age, years | 64.4 ± 7 | 61.0 ± 11 | 61 ± 14 | 0.617 |
| BMI, kg/m2 | 25.4 ± 4.2 | 27.4 ± 4.5 | 27.2 ± 4.2 | 0.364 |
| Current smokers, n (%) | 3 (17) | 9 (56) | – | < 0.001 |
| Pack-years | 51.47 ± 15.52 | 39.87 ± 19.09 | – | 0.072 |
| Diabetes Mellitus, n (%) | 1 (6) | 6 (37.5) | – | 0.005 |
| Fast basal glucose, mmol/L | 5.2 [4.7–6.6] | 6.5 [5.2–7.3] | 5.3 [4.9–6.3] | 0.056 |
| Systemic hypertension, n (%) | 8 (34.8) | 7 (43.7) | 5 (31.3) | 0.896 |
| Inhaled CS, n (%) | 5 (29.0) | 0 (0) | 1 (7) | 0.039 |
| FVC, L | 3.3 ± 0.7 | 4 ± 0.9 | 3.5 ± 1 | 0.079 |
| FVC, % predicted | 89 ± 14 | 101 ± 17 | 111 ± 23 | 0.008 |
| FEV1, L | 1.9 ± 0.5 | 3 ± 0.6 | 2.7 ± 0.8 | < 0.001 |
| FEV1, % predicted | 64 ± 16 | 97 ± 14 | 106 ± 23 | < 0.001 |
| % FEV1/FVC | 57 ± 10 | 76 ± 5 | 77 ± 5 | < 0.001 |
| DLCO,% predicted | 69 ± 14 | 89 ± 17 | 93 ± 18 | < 0.001 |
| Leukocytes count, x10E9/L | 8.7 ± 1.9 | 8.2 ± 2 | 6.9 ± 1.5 | 0.038 |
| C-reactive protein, mg/L | 5.4 [2.1–10.6] | 2.1 [1.0–10.9] | 1.8 [1–2.7] | 0.028 |
Data are presented as mean ± SD or median [25th–75th percentile]
COPDChronic Obstructive Pulmonary Disease, NOS Non-obstructed smokers, NS Never smokers, BMI Body mass index, CS Corticosteroids, FVC Forced vital capacity, FEV1 Forced expiratory volume in one second, DLCO Diffusing lung capacity for carbon monoxide. A p-value < 0.05 was considered statistically significant