Table 2. Leading estimated gene transcription levels-metabolite pairs in EAs.

Trait	Gene	Tissue	Beta	P-value
Androsterone sulfate	UGT2B15	Transverse colon	0.65	0.17
Androsterone sulfate	UGT2B17	Lung	0.33	0.36
5-Dodecenoate	SEMA4G	Nerve tibial	0.24	1.9 × 10−3
5-Dodecenoate	SCD	Adipose subcutaneous	0.28	5.14 × 10−3
Glycocholenate sulfate	FDX1	Whole blood	0.31	2.93 × 10−6
Heptanoate	NAT8	Skin sun exposed lower leg	−0.20	2.80 × 10−9
Heptanoate	TPRKB	Artery tibial	0.15	1.39 × 10−6
Heptanoate	ALMS1	Pancreas	−0.08	1.49 × 10−5
Hexanoylcarnitine	BCHE	Heart atrial appendage	−0.75	9.57 × 10−6
13-HODE + 9-HODE	FADS1	Cerebellum	−0.17	3.56 × 10−9
13-HODE + 9-HODE	FADS2	Muscle skeletal	0.34	2.85 × 10−7
13-HODE + 9-HODE	TMEM258	Muscle skeletal	0.75	1.12 × 10−8
13-HODE + 9-HODE	BEST1	Heart atrial appendage	0.33	2.29 × 10−5
13-HODE + 9-HODE	DAGLA	Cells transformed fibroblasts	−0.26	7.72 × 10−4