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. 2018 Feb 12;145(2):111–124. doi: 10.1111/jnc.14290

Figure 3.

Figure 3

Effect of the positive allosteric mGluR5 modulator, S‐(4‐Fluoro‐phenyl)‐{3‐[3‐(4‐fluoro‐phenyl)‐[1,2,4]‐oxadiazol‐5‐yl]‐piperidin‐1‐yl}‐methanone (ADX47273), on extracellular glutamate efflux in the mPFC (n = 10 rats). (a) All rats received vehicle (p.o.; time bin zero). Three hours later, all rats received ADX47273 (100 mg/kg, p.o.; time bin zero). Data points represent mean ± 1 SEM. Repeated‐measures anova, Bonferroni post hoc, *p < 0.05, **p < 0.01, ADX47273 versus vehicle treatment. (b) area under the curve (AUC) presented, as a histogram, for vehicle and ADX47273 conditions. (c) Summary of experimental timeline (BL = baseline).