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. 2018 Feb 12;145(2):111–124. doi: 10.1111/jnc.14290

Figure 4.

Figure 4

Effect of the negative allosteric mGluR5 modulator, RO4917523, on extracellular glutamate efflux in the mPFC (n = 8 rats). (a) All rats received vehicle (p.o.; time bin zero). Three hours later, rats received RO4917523 (0.3 mg/kg, p.o.; time bin zero). Data points represent mean ± 1SEM. Repeated‐measures anova, Bonferroni post hoc, *< 0.05, **< 0.01, RO4917523 versus vehicle condition. (b) area under the curve (AUC) presented, as a histogram, for vehicle and RO4917523 conditions. (c) Summary of experimental timeline (BL = baseline).