Table 1.
Baseline subject characteristics and pulmonary function data
| Older (n = 22) |
Younger (n = 22) |
||||
|---|---|---|---|---|---|
| Men (n = 10) | Women (n = 12) | Men (n = 11) | Women (n = 11) | P Value | |
| Age, yr | 70 ± 2 | 66 ± 2 | 26 ± 1 | 24 ± 1 | *P < 0.05 |
| Height, cm | 173 ± 2 | 163 ± 2 | 176 ± 2 | 166 ± 2 | †P < 0.05 |
| Body mass, kg | 76 ± 4 | 65 ± 3 | 73 ± 3 | 58 ± 2 | †P < 0.05 |
| BMI, kg/m2 | 25 ± 1 | 25 ± 1 | 23 ± 1 | 21 ± 1 | *P < 0.05 |
| FVC, liter | 4.30 ± 0.12 | 3.46 ± 0.20 | 5.46 ± 0.22 | 4.26 ± 0.18 | *†P < 0.05 |
| FVC, %predicted | 102 ± 2 | 108 ± 3 | 101 ± 3 | 104 ± 3 | |
| FEV1, liter | 3.06 ± 0.13 | 2.49 ± 0.16 | 4.27 ± 0.19 | 3.55 ± 0.13 | *†P < 0.05 |
| FEV1, %predicted | 102 ± 4 | 104 ± 4 | 99 ± 3 | 106 ± 2 | |
| FEV1/FVC | 71 ± 2 | 71 ± 2 | 79 ± 2 | 82 ± 2 | *P < 0.05 |
| FEV1/FVC, %predicted | 99 ± 3 | 96 ± 2 | 94 ± 2 | 95 ± 1 | |
| PEF, l/s | 8.63 ± 0.42 | 6.82 ± 0.38 | 10.79 ± 0.39 | 7.69 ± 0.15 | *†P < 0.05 |
| FEF25–75, l/s | 2.10 ± 0.29 | 1.90 ± 0.12 | 4.18 ± 0.18 | 3.67 ± 0.22 | *P < 0.05 |
| FEF25–75, %predicted | 82 ± 11 | 77 ± 4 | 91 ± 3 | 97 ± 6 | |
| TLC, liter | 6.84 ± 0.31 | 5.57 ± 0.26 | 6.89 ± 0.23 | 5.42 ± 0.20 | †P < 0.05 |
| TLC, %predicted | 102 ± 3 | 108 ± 3 | 102 ± 3 | 103 ± 2 | |
| VC, liter | 4.45 ± 0.14 | 3.57 ± 0.18 | 5.56 ± 0.21 | 4.32 ± 0.17 | *†P < 0.05 |
| VC, %predicted | 101 ± 3 | 109 ± 3 | 103 ± 4 | 102 ± 2 | |
| IC, liter | 3.03 ± 0.26 | 2.39 ± 0.21 | 3.48 ± 0.17 | 2.77 ± 0.15 | *†P < 0.05 |
| IC, %predicted | 100 ± 8 | 100 ± 9 | 99 ± 5 | 115 ± 5 | |
| FRC, liter | 3.90 ± 0.24 | 3.18 ± 0.16 | 3.41 ± 0.17 | 2.64 ± 0.12 | *†P < 0.05 |
| FRC, %predicted | 97 ± 4.25 | 108 ± 4 | 104 ± 6 | 92 ± 4 | |
| RV, liter | 2.39 ± 0.24 | 1.96 ± 0.11 | 1.33 ± 0.12 | 1.07 ± 0.07 | *P < 0.05 |
| RV, % predicted | 95 ± 8 | 100 ± 5 | 90 ± 11 | 81 ± 5 | |
| DLco, ml·min−1·mmHg−1 | 27 ± 2 | 23 ± 1 | 33 ± 2 | 25 ± 1 | *†P < 0.05 |
| DLco, %predicted | 107 ± 6 | 105 ± 4 | 111 ± 4 | 105 ± 4 | |
| MIP, cmH2O | −103 ± 8 | −76 ± 6 | −138 ± 10 | −106 ± 7 | *†P < 0.05 |
| MIP, %predicted | 98 ± 8 | 108 ± 6 | 107 ± 5 | 115 ± 6 | |
| MEP, cmH2O | 151 ± 16 | 109 ± 8 | 178 ± 11 | 142 ± 9 | *†P < 0.05 |
| MEP, % predicted | 78 ± 8 | 81 ± 6 | 74 ± 5 | 90 ± 6 | |
| Cl, l/cmH2O1 | 0.29 ± 0.01 | 0.28 ± 0.03 | 0.31 ± 0.02 | 0.26 ± 0.02 | |
| Pst 100%TLC, cmH2O−1 | 19 ± 2 | 20 ± 2 | 28 ± 1 | 31 ± 1 | *P < 0.05 |
| Pst 50%VC, cmH2O−1 | 4.8 ± 0.4 | 5.5 ± 0.6 | 6.4 ± 0.5 | 6.5 ± 0.2 | *P < 0.05 |
All data are presented as means ± SE. BMI, body mass index; FVC, forced vital capacity; FEV1, forced expired volume in 1 s; PEF, peak expiratory flow; FEF25–75, forced expired flow between 25 and 75% of FVC; TLC, total lung capacity; VC, vital capacity; IC, inspiratory capacity; FRC, functional residual capacity; RV, residual volume; DLco, diffusion capacity of the lung for carbon monoxide; MIP, maximal inspiratory pressure; MEP, maximal expiratory pressure; Cl, lung compliance; Pst 100%TLC, static recoil pressure of the lungs at 100% of TLC; Pst 50%VC, static recoil pressure of the lungs at 50% of vital capacity.
*
Older vs. younger subjects.
†
Men vs. women.