Table 1.
Characteristics of the study cohort (n = 159)
| Mean age ± SD, years | 72.4±10.1 |
| Male, % | 55 |
| Median years of education (range) | 5 (1–7) |
| Vascular risk factors, % | |
| Hypertension | 96 |
| Hyperlipidemia | 72 |
| Current smoking | 15 |
| Diabetes mellitus | 38 |
| Obesity | 19 |
| History of manifest arterial disease | 21 |
| Diagnosis, % | |
| No objective cognitive impairment | 17 |
| Mild cognitive impairment | 35 |
| Vascular dementia | 6 |
| Alzheimer disease | 36 |
| Dementia – othera | 6 |
| Imaging characteristics | |
| Patients with lacunes, % | 28 |
| Patients with nonlacunar infarcts, % | 20 |
| Patients with microbleeds, %b | 42 |
| Median total WMH volume (range) as % of WBWM | 1.77 (0.02–28.51) |
| Mean brain parenchymal fraction ± SDC | 0.66±0.07 |
| Mean FA WBWM ± SD (range) | 0.380±0.026 (0.279–0.433) |
| Mean MD WBWM ± SD (range), ×10−3 mm2/s | 0.979±0.062 (0.829–1.151) |
WMH, white matter hyperintensity; WBWM, whole brain white matter; FA, fractional anisotropy; MD, mean diffusivity.
a
Primary progressive aphasia, cortical basal syndrome, progressive supranuclear palsy, frontotemporal dementia, and 1 case of a delayed diagnosis pending further examinations.
b
Data missing in 3 cases.
c
Measure for brain atrophy, calculated by dividing total brain volume by intracranial volume.